abstract：:This study determined the effects of estrogen loss and replacement therapy on learning and memory function in monkeys (Macaca fascicularis). The ability to learn, remember, and perform reversals of object discriminations and the accuracy on a spatial delayed response task were found to be comparable in young adult sur...

journal_title：Behavioral neuroscience

authors： Voytko ML

更新日期：2000-12-01 00:00:00

abstract：:These experiments examined the sufficiency of pairing an odor with either intrabulbar activation of noradrenergic beta-receptors or pharmacological stimulation of the locus coeruleus to support learned odor preferences in Postnatal Day 6-7 rat pups. The results showed that pups exposed to odor paired with beta-recepto...

journal_title：Behavioral neuroscience

authors： Sullivan RM,Stackenwalt G,Nasr F,Lemon C,Wilson DA

更新日期：2000-10-01 00:00:00

abstract：:This study used anatomical cues to suggest a functional dissociation between the roles of the entorhinal cortex and the hippocampus in learning. The authors proposed that the highly convergent inputs to the entorhinal cortex indicate this region may be particularly important for selecting or compressing information. T...

journal_title：Behavioral neuroscience

authors： Shohamy D,Allen MT,Gluck MA

更新日期：2000-10-01 00:00:00

abstract：:Transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) from olfactory sensory neurons to the olfactory bulb as well as odor detection and discrimination were examined in rats in which each nasal epithelium had been irrigated with 0.1-0.5 ml 5% zinc sulfate. After treatment, rats showed few or no deficits ...

journal_title：Behavioral neuroscience

authors： Slotnick B,Glover P,Bodyak N

更新日期：2000-08-01 00:00:00

abstract：:Activation of memory retrieval after weak learning (WL), during either the short- or intermediate-term stages of memory in day-old chickens, resulted in the strengthening of the memory to levels normally associated with strong learning. Administration of the calcium channel antagonist lanthanum chloride, the glutamate...

journal_title：Behavioral neuroscience

authors： Summers MJ,Crowe SF,Ng KT

更新日期：2000-08-01 00:00:00

abstract：:In infant rats, administration of the alpha2 adrenoceptor agonist clonidine simultaneously evokes ultrasound production and bradycardia. In this study the authors examined in 8-day-old rats whether these 2 responses to clonidine are causally related. In Experiment 1 pups were pretreated with saline or prenalterol (0.1...

journal_title：Behavioral neuroscience

authors： Blumberg MS,Kreber LA,Sokoloff G,Kent KJ

更新日期：2000-06-01 00:00:00

abstract：:Habituation has traditionally been considered a nonassociative form of learning. However, recent research suggests that retention of this nonassociative form of learning may be aided by associations formed during training. An example of this is context conditioning, in which animals that are trained and tested in the ...

journal_title：Behavioral neuroscience

authors： Rankin CH

更新日期：2000-06-01 00:00:00

abstract：:Neuromuscular impairment by ethanol likely involves complex effects on balance, gait, muscle strength, and other features of motor coordination. The present experiments showed that relative sensitivity to ethanol-induced motor impairment in serotonin 1B (5-HT(1B)) null mutant and control mice was task dependent. We fo...

journal_title：Behavioral neuroscience

authors： Boehm SL 2nd,Schafer GL,Phillips TJ,Browman KE,Crabbe JC

更新日期：2000-04-01 00:00:00

abstract：:The role of the pedunculopontine tegmental nucleus (PPTg) in stimulus-reward learning was assessed by testing the effects of PPTg lesions on performance in visual autoshaping and conditioned reinforcement (CRf) paradigms. Rats with PPTg lesions were unable to learn an association between a conditioned stimulus (CS) an...

journal_title：Behavioral neuroscience

authors： Inglis WL,Olmstead MC,Robbins TW

更新日期：2000-04-01 00:00:00

abstract：:The nature of anticipatory responding in rats with unilateral subthalamic nucleus lesions was examined. Rats were trained to respond toward visual targets that were preceded by 1 of 4 different cues. For normal rats, a cue invokes an involuntary attentional orienting that enhances processing of the target at the locat...

journal_title：Behavioral neuroscience

authors： Phillips JM,Brown VJ

更新日期：2000-02-01 00:00:00

abstract：:Previous electrophysiological studies and computational modeling suggest the hypothesis that cholinergic neuromodulation may reduce olfactory associative interference during learning (M. E. Hasselmo, B. P. Anderson, & J. M. Bower, 1992; M. E. Hasselmo & J. M. Bower, 1993). These results provide behavioral evidence sup...

journal_title：Behavioral neuroscience

authors： De Rosa E,Hasselmo ME

更新日期：2000-02-01 00:00:00

abstract：:Female ovariectomized (OVX) and sham-OVX rats were trained in a task designed to assess sustained attention. After achieving asymptotic performance, OVX rats did not exhibit the impairment in performance over blocks of trials (i.e., the vigilance decrement) observed in sham-OVX rats. Furthermore, OVX rats' performance...

journal_title：Behavioral neuroscience

authors： McGaughy J,Sarter M

更新日期：1999-12-01 00:00:00

abstract：:Access to a running wheel combined with restricted feeding produced body weight loss at an equivalent rate in male and female litter-mate rats (Experiment 1). Thus, despite weighing less and running more, females were not more vulnerable to this procedure. When factors influencing weight loss were varied, no sex diffe...

journal_title：Behavioral neuroscience

authors： Boakes RA,Mills KJ,Single JP

更新日期：1999-10-01 00:00:00

abstract：:PDAPP transgenic mice have been shown to develop age dependently much of the cerebral histopathology associated with Alzheimer's disease. PDAPP mice (3-10 months old) were tested in a battery of memory tasks to determine whether they develop memory-behavioral deficits and whether these deficits occur before or after a...

journal_title：Behavioral neuroscience

authors： Dodart JC,Meziane H,Mathis C,Bales KR,Paul SM,Ungerer A

更新日期：1999-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a potent endogenous stimulator of food intake. In addition to stimulating increased food intake, when paired with a novel-flavored solution, NPY produces an aversion to that flavor. Hence, exogenous NPY elicits 2 seemingly opposing behaviors, increased feeding and the formation of a conditioned...

journal_title：Behavioral neuroscience

authors： Madden LJ,Seeley RJ,Woods SC

更新日期：1999-08-01 00:00:00

abstract：:The striatum is implicated in response selection and performance, the dorsal striatum in sensorimotor control and habit learning, and the ventral striatum in motivation and rewarded behaviors. Ventral striatal lesions produce performance changes on food-reinforced, progressive-ratio (PR) schedules, but the effects of ...

journal_title：Behavioral neuroscience

authors： Eagle DM,Humby T,Dunnett SB,Robbins TW

更新日期：1999-08-01 00:00:00

abstract：:Exposure to 3 moderately intense (1-mA) tailshocks has been shown to lower vocalization thresholds to both heat and shock. Previous shock exposure also facilitates the acquisition of conditioned fear as measured by freezing. These observations suggest that shock induces hyperalgesia (enhanced pain). This study explore...

journal_title：Behavioral neuroscience

authors： McLemore S,Crown ED,Meagher MW,Grau JW

更新日期：1999-06-01 00:00:00

abstract：:The effects of various doses (40 microg/kg/hr, 300 microg/kg/hr, 600 microg/kg/hr or placebo) of hydrocortisone on tasks assessing working and declarative memory function were measured in 4 groups of 10 young men. During the infusion, participants were given an item-recognition working memory task, a paired-associate ...

journal_title：Behavioral neuroscience

authors： Lupien SJ,Gillin CJ,Hauger RL

更新日期：1999-06-01 00:00:00

abstract：:The C. elegans mutants, lrn-1 and lrn-2, are impaired in associative learning using conditioned taste cues. Both mutants are defective in associative learning about appetitive and aversive events, indicating that lrn-1 and lrn-2 exert effects across motivational boundaries. In a new olfactory associative learning para...

journal_title：Behavioral neuroscience

authors： Morrison GE,Wen JY,Runciman S,van der Kooy D

更新日期：1999-04-01 00:00:00

abstract：:This study examined the relative roles of distinct striatal areas in response processing. Rats were trained on a reaction time task that enabled performance on each side of the rat's body to be assessed independently. Rats then received unilateral lesions of the whole dorsal striatum or restricted medial or lateral le...

journal_title：Behavioral neuroscience

authors： Brasted PJ,Robbins TW,Dunnett SB

更新日期：1999-04-01 00:00:00

abstract：:The authors have previously demonstrated that Purkinje cell-degeneration (pcd) mutant mice are impaired in eyeblink conditioning (L. Chen et al., 1996a). The present study addresses the following 3 questions: (a) whether pcd mice perceive the conditioned and unconditioned stimuli as well as the wild-type mice, (b) whe...

journal_title：Behavioral neuroscience

authors： Chen L,Bao S,Thompson RF

更新日期：1999-02-01 00:00:00

abstract：:Using Hermissenda as subjects, massed-trials training deficits were examined. Associative pairings of light and rotation induced a progressively greater conditioned foot contraction in response to light as the intertrial interval (ITI) was extended (up to 8 min). In contrast, a short ITI (30 s) produced no evidence of...

journal_title：Behavioral neuroscience

authors： Muzzio IA,Ramirez RR,Talk AC,Matzel LD

更新日期：1999-02-01 00:00:00

abstract：:Rats treated chronically with the dopamine agonist quinpirole (0.5 mg/kg, twice weekly x 10) met 5 criteria for performance of compulsive checking. Specifically, in a large open-field with single small objects in 4 of 25 locales, quinpirole rats revisited two places/objects excessively often and rapidly, compared with...

journal_title：Behavioral neuroscience

authors： Szechtman H,Sulis W,Eilam D

更新日期：1998-12-01 00:00:00

abstract：:The aim of this study was to investigate the effects of postnatal choline supplementation on neurochemical and behavioral parameters in preweanling BALB/cByJ mice. Mouse pups were injected daily subcutaneously with choline chloride (0.85 mM/g body weight) from Postnatal Day (PND) 1 to PND 16. Pups performed a passive ...

journal_title：Behavioral neuroscience

authors： Ricceri L,Berger-Sweeney J

更新日期：1998-12-01 00:00:00

abstract：:Mice unable to synthesize dopamine (DA) in dopaminergic neurons were generated by gene-targeting techniques (Q.-Y. Zhou & R. D. Palmiter, 1995). These dopamine-deficient (DA-/-) mice required daily administration of 3,4-dihydroxyphenylalanine (L-DOPA) for survival beyond 2 to 3 weeks of age. This treatment stimulated ...

journal_title：Behavioral neuroscience

authors： Szczypka MS,Zhou QY,Palmiter RD

更新日期：1998-10-01 00:00:00

abstract：:Central neurokinin-1 (NK-1) receptors are thought to modulate aversion, whereas the periaqueductal gray matter (PAG) is a common pathway for the integration of fear behaviors. The authors determined whether injection of an NK-1 agonist (GR73632) into subregions of the PAG would alter fear-related behaviors. Behavioral...

journal_title：Behavioral neuroscience

authors： Mongeau R,De Oca BM,Fanselow MS,Marsden CA

更新日期：1998-10-01 00:00:00

abstract：:Gerbils aged 3 months and 24+ months were subjected to 5 min of global forebrain ischemia and tested in a radial arm maze (1 trial/day, 50 days). Compared with age-matched, sham-operated controls, ischemic animals were impaired on measures of both working and reference memory. Aged animals were impaired on working mem...

journal_title：Behavioral neuroscience

authors： Schwartz C,Wishart TB,Ijaz S,Shuaib A

更新日期：1998-08-01 00:00:00

abstract：:Previous research conducted in monkeys and rats has established that the perirhinal cortex is critically involved in object- or stimulus-recognition memory, whereas other research suggests this region may contribute to memory for object discriminations. These findings do not rule out the possibility that the perirhina...

journal_title：Behavioral neuroscience

authors： Wiig KA,Burwell RD

更新日期：1998-08-01 00:00:00

abstract：:The intermediate and medial hyperstriatum ventrale (IMHV) of the chick forebrain is a site of recognition memory for the learning process of imprinting. The results reported here demonstrate that neural cell adhesion molecules (NCAMs) play a time-dependent role in this recognition memory. Dark-reared chicks were train...

journal_title：Behavioral neuroscience

authors： Solomonia RO,McCabe BJ,Horn G

更新日期：1998-06-01 00:00:00

abstract：:The glutamate analog, L-2-amino-4-phosphonobutyric acid (L-AP4) is a selective agonist for several members of the metabotropic glutamate receptor (mGluR) family. Activation of presynaptic mGluRs by L-AP4 causes a suppression of synaptic transmission in the central nervous system. In this study, the role of 1 subtype o...

journal_title：Behavioral neuroscience

authors： Gerlai R,Roder JC,Hampson DR

更新日期：1998-06-01 00:00:00

abstract：:Microstructural analysis of licking behavior in the rat was conducted (a) to describe in detail the characteristics of benzodiazepine-induced changes in ingestion and (b) to determine if the changes are consistent with an alteration in palatability. The effects of the benzodiazepine receptor (BZR) agonist midazolam (0...

journal_title：Behavioral neuroscience

authors： Higgs S,Cooper SJ

更新日期：1998-04-01 00:00:00

abstract：:Rats with bilateral, electrolytic lesions of perirhinal cortex (PRC), lateral entorhinal cortex (LEC), or combined lesions (PRLE) were impaired relative to controls (sham) during initial acquisition in the Morris water maze, although all groups were eventually able to learn to locate the platform. A further deficit in...

journal_title：Behavioral neuroscience

authors： Liu P,Bilkey DK

更新日期：1998-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the sensorimotor skills of a spontaneous mouse mutant, Purkinje cell degeneration (PCD), marked by selective cerebellar cortical atrophy on a treadmill activated at 1 of 2 speeds and at 1 of 3 slopes, requiring forward movements to avoid footshocks. There was no difference in ...

journal_title：Behavioral neuroscience

authors： Le Marec N,Lalonde R

更新日期：1998-02-01 00:00:00

abstract：:Adult rats that were isolated from the mother and nest for 1 hr per day from Postnatal Day 2 to 9 were studied. Controls consisted of handled littermates as well as separate litters that were never handled. As adults, animals were given either a pharmacological challenge (1.0 or 2.0 mg/kg amphetamine) or an environmen...

journal_title：Behavioral neuroscience

authors： Kehoe P,Shoemaker WJ,Triano L,Callahan M,Rappolt G

更新日期：1998-02-01 00:00:00

abstract：:This study examined the neural substrates underlying the development of a conditioned place preference (CPP) to morphine (2 mg/kg x 3 pairings) by testing whether lesions of 7 different neural sites block a morphine-induced CPP. Lesions of the pedunculopontine tegmental nucleus (PPTg), the periaqueductal gray (PAG), o...

journal_title：Behavioral neuroscience

authors： Olmstead MC,Franklin KB

更新日期：1997-12-01 00:00:00

abstract：:Gerbils show a postischemic increase in locomotor activity that correlates to the extent of neuron loss in the hippocampal CA1 subfield. It has been suggested that this hyperactivity is predictive of neuron loss in the CA1. In this study the correlation between postischemic hyperactivity and neuron loss in several hip...

journal_title：Behavioral neuroscience

authors： Andersen MB,Zimmer J,Sams-Dodd F

更新日期：1997-12-01 00:00:00

abstract：:Pinealectomized lizards (Podarcis sicula) whose locomotor rhythms were recorded in constant temperature (29 degrees C) and darkness were subdivided into 2 groups of hosts: Each belonging to the 1st group (experimentals) received from a donor a pineal gland, and each belonging to the 2nd one (controls) received a piece...

journal_title：Behavioral neuroscience

authors： Foà A,Bertolucci C,Marsanich A,Innocenti A

更新日期：1997-10-01 00:00:00

abstract：:A unilateral microinjection of morphine into the amygdala impaired fear conditioning to both a conditioned stimulus (CS) paired with shock and the context where shock occurred, whereas a microinjection of morphine into the nucleus accumbens (NA) spared fear conditioning to the CS but impaired, in a dose-dependent and ...

journal_title：Behavioral neuroscience

authors： Westbrook RF,Good AJ,Kiernan MJ

更新日期：1997-10-01 00:00:00

abstract：:Trace eyeblink classical conditioning was assessed in patients with bilateral medial-temporal amnesia and matched control participants who had previously shown equivalent delay eyeblink conditioning (J. D. E. Gabrieli et al., 1995). The silent trace interval varied for durations of 500, 750, or 1,000 ms in successive ...

journal_title：Behavioral neuroscience

authors： McGlinchey-Berroth R,Carrillo MC,Gabrieli JD,Brawn CM,Disterhoft JF

更新日期：1997-10-01 00:00:00

abstract：:Acute mid-thoracic spinal cord transection eliminates hindlimb air-stepping in neonatal rats suspended in harnesses and administered L-DOPA. Because spinal cord transection eliminates all descending inputs to the hindlimb locomotor circuits, this experiment determined if coadministration of L-DOPA and quipazine (serot...

journal_title：Behavioral neuroscience

authors： McEwen ML,Van Hartesveldt C,Stehouwer DJ

更新日期：1997-08-01 00:00:00